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BIOMARKER GENERATOR

Introducing the B-100 Biomarker Generator. The B-100 is smaller, easier to install and simpler to operate than conventional cyclotrons.

Biomarker Generator

The B-100 produces PET biomarkers and radioisotopes on demand. An integrated solution, the B-100 encompasses an entire PET production lab in a 300 square feet (30 sq meter) room. It includes a self-shielded mini-cyclotron for producing the positron emitting F-18 isotope and microchemistry system for labeling specific molecules with the positron emitting isotopes. The unique B-100 system is significantly smaller, easier to install and simpler to operate than conventional cyclotrons. 

Mini-Cyclotron

KEY FEATURES OF THE B-100 SELF-SHIELDED MINI-CYCLOTRON

  • Low power 
  • Simple one button operation  
  • Fast production of radioisotopes – dose available when needed 
  • Designed for reliability 
  • Easy access to target and ion source for simple replacement 
  • Turbo pump vs oil based diffusion pump 

Accelerator Specifications

ACCELERATOR SPECIFICATIONS OF THE B-100 SELF-SHIELDED MINI-CYCLOTRON:

  • 7.5 MeV positive ion cyclotron 
  • 3 internal targets 
  • Production rate of *≥2.0 mCi/min [18F] fluoride 
  • 1.16 T magnet 
  • <5 µA Beam current for F-18 production

* depending on target current and duration of bombardment

Micro-Chemistry

ABT’s INTEGRATED SOLUTION INCLUDES MICRO-CHEMISTRY WITH AUTOMATED QUALITY CONTROL

  • Micro-Chemistry with single use Dose Synthesis Card
  • Replaceable precursor/reagent kits
  • Programmable and capable of producing any one or two step [18F] fluoride ion based process
  • Self-shielded, installed adjacent to the accelerator shield
  • [18F] FDG/NaF Module

Quality Control Features:

FEATURES OF OUR INTEGRATED QUALITY CONTROL MODULE

  • Automated quality control sample from final product vial
  • Quality control tests for each dose
  • Quality control tests based on pharmacopeial standards
  • Embedded methods
  • Ph, volatile organics, radiochemical and radionuclidic purity, organic solvents, color/clarity, filter integrity
  • HPLC, rad detector, ph meter, microsensors
  • Dose record for each dose generated

Self-Shielding

FEATURES OF OUR COMPACT SELF-SHIELDING SOLUTION

  • Self-shielded, eliminating the need for a bunker to house the system.
  • Shield opens vertically for servicing and provides radiation protection of <1 mR per hour in the typical room size specified.
  • Micro-Chemistry module is also self-shielded and can be installed adjacent to the cyclotron shield for direct connection within the same room.